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What safety considerations should clinicians evaluate

Regarding the inflammatory component in neuronal disorders, ALA and DHLA inhibit inflammasomes in neural tissues by decreasing pro-inflammatory mediators, such as interleukin-2 (IL-2), IFN-, and TNF-, increasing anti-inflammatory cytokines such as interleukin-10 (IL-10), and regulating the transcription of nuclear factors Nrf2 and NF-B in physiological processes

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Silymarin, a natural compound from the milk thistle plant, has a protective mechanism that prevents the reception of xenobiotics, including toxic substances found in mushrooms, by hepatocyte surfaces